Adapter proteins in lymphocyte antigen-receptor signaling

P S Myung; N J Boerthe; G A Koretzky

doi:10.1016/s0952-7915(00)00085-6

Adapter proteins in lymphocyte antigen-receptor signaling

Curr Opin Immunol. 2000 Jun;12(3):256-66. doi: 10.1016/s0952-7915(00)00085-6.

Authors

P S Myung¹, N J Boerthe, G A Koretzky

Affiliation

¹ Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.

PMID: 10781404
DOI: 10.1016/s0952-7915(00)00085-6

Abstract

Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.

Publication types

Review

MeSH terms

Lymphocytes / immunology*
Models, Immunological
Proteins / metabolism*
Receptors, Antigen / metabolism*
Receptors, Antigen, B-Cell / metabolism
Receptors, Antigen, T-Cell / metabolism
Signal Transduction*

Substances

Proteins
Receptors, Antigen
Receptors, Antigen, B-Cell
Receptors, Antigen, T-Cell