Abstract
We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity.
MeSH terms
-
Adenosine Triphosphate / analogs & derivatives*
-
Adenosine Triphosphate / chemical synthesis
-
Adenosine Triphosphate / chemistry
-
Adenosine Triphosphate / pharmacology
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology
-
Enzyme Inhibitors / chemical synthesis
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Gram-Positive Bacteria / drug effects
-
Gram-Positive Bacteria / enzymology
-
Microbial Sensitivity Tests
-
Structure-Activity Relationship
-
Topoisomerase II Inhibitors*
Substances
-
Anti-Bacterial Agents
-
Enzyme Inhibitors
-
Topoisomerase II Inhibitors
-
Adenosine Triphosphate