Abstract
A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology*
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Candida / drug effects
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Ferrous Compounds / chemistry
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Ferrous Compounds / pharmacology*
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Fluconazole / chemistry
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Fluconazole / pharmacology*
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Metallocenes
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Microbial Sensitivity Tests
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Species Specificity
Substances
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Antifungal Agents
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Ferrous Compounds
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Metallocenes
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Fluconazole
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ferrocene