Abstract
Chemical investigation of the Et(2)O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human bronchopulmonary cancer cells (NSCLC-N6) with an IC(50) of 12 and 6.3 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Imidazoles / isolation & purification*
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Imidazoles / pharmacology
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Indoles / isolation & purification*
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Indoles / pharmacology
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Magnetic Resonance Spectroscopy
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Piperazines / isolation & purification
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Piperazines / pharmacology
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Porifera / chemistry*
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Spectrophotometry, Ultraviolet
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Tissue Extracts / chemistry
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Tissue Extracts / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Imidazoles
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Indoles
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Piperazines
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Tissue Extracts
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topsentin