Abstract
Unique C-C-bridged bis-isoflavones 5, 8, and 9 were obtained by reaction of 2-bromomethyl-7,4'-dimethoxyisoflavone 4 with ethyl cyanoacetate anion or tetraethylammonium cyanide or by Pd-catalyzed ethoxycarbonylation, respectively. The phenolic carboxylic acid 7 is available from 5 in two steps.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkylation
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Bridged-Ring Compounds / chemistry*
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Carboxylic Acids / chemistry
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Catalysis
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Crystallography, X-Ray
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Cyanides
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Dimethyl Sulfoxide
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Indicators and Reagents
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Isoflavones / chemistry*
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Lead
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
Substances
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Bridged-Ring Compounds
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Carboxylic Acids
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Cyanides
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Indicators and Reagents
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Isoflavones
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Oligopeptides
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Lead
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Dimethyl Sulfoxide