Abstract
The 8-hour in vitro activity of serum-simulated concentrations of amoxicillin (obtained after 875 mg oral dose) and cefotaxime (obtained after a 1 g i.v. dose), against 20 strains of the 5 Streptococcus pneumoniae serotypes most prevalent in Spain, was explored. Despite a greater initial inocula decrease observed with cefotaxime against the resistant strains at the first sampling time, a decrease > or =99.9% was obtained with both beta-lactams from 6h onwards against the penicillin-susceptible strains; the same was observed for the penicillin-resistant strains with amoxicillin but not with cefotaxime.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Amoxicillin / administration & dosage
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Amoxicillin / pharmacology*
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Cefotaxime / administration & dosage
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Cefotaxime / pharmacology*
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Cephalosporins / administration & dosage
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Cephalosporins / pharmacology*
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Humans
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Infusions, Intravenous
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Microbial Sensitivity Tests / methods
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Penicillin Resistance*
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Penicillins / administration & dosage
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Penicillins / pharmacology*
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology
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Spain / epidemiology
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects*
Substances
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Cephalosporins
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Penicillins
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Amoxicillin
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Cefotaxime