Abstract
The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E2. Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10(-5) M) did not block this short-lived enhancement. Thus, it does not seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bradykinin / pharmacology
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Capsaicin / analogs & derivatives*
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Capsaicin / pharmacology
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Dinoprostone / pharmacology
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Drug Interactions / physiology*
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Ganglia, Spinal / drug effects
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Ganglia, Spinal / metabolism
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Hydrogen-Ion Concentration*
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Inflammation / chemically induced*
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Inflammation / pathology
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Inflammation / physiopathology*
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Inflammation Mediators / metabolism*
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Inflammation Mediators / pharmacology*
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Male
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Nerve Fibers / drug effects
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Nerve Fibers / metabolism
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Nociceptors / drug effects*
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Nociceptors / metabolism*
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Oxytocics / pharmacology
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Protons / adverse effects
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Rats
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Rats, Wistar
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Serotonin / pharmacology
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Skin / drug effects*
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Skin / innervation*
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Skin / physiopathology
Substances
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Inflammation Mediators
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Oxytocics
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Protons
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Serotonin
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Dinoprostone
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capsazepine
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Capsaicin
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Bradykinin