Abstract
Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibodies, Protozoan / blood*
-
Antigens, Protozoan*
-
Cattle
-
Immunization Schedule
-
Protozoan Proteins / genetics
-
Protozoan Proteins / immunology*
-
Protozoan Vaccines / immunology*
-
Recombinant Proteins / immunology
-
Theileria annulata / growth & development
-
Theileria annulata / immunology*
-
Theileria parva / growth & development
-
Theileria parva / immunology*
-
Theileriasis / immunology
-
Theileriasis / parasitology
-
Theileriasis / prevention & control*
Substances
-
Antibodies, Protozoan
-
Antigens, Protozoan
-
Protozoan Proteins
-
Protozoan Vaccines
-
Recombinant Proteins
-
p67 antigen, Theileria
-
SPAG-1 antigen, Theileria annulata