Abstract
We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Biomarkers / blood
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Calcium Signaling / immunology
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Chemokines / metabolism
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Cytokines / metabolism
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Fungi / immunology
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Gram-Negative Bacteria / immunology
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Gram-Positive Bacteria / immunology
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Humans
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Immunoglobulins / biosynthesis
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Immunoglobulins / genetics
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Immunoglobulins / physiology
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Inflammation / immunology
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Inflammation / microbiology
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Macrophage Activation / immunology
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Membrane Glycoproteins / blood
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Membrane Proteins
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Molecular Sequence Data
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Molecular Weight
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Monocytes / immunology*
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Monocytes / metabolism*
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Monocytes / microbiology
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Multigene Family / immunology
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Neutrophil Activation / immunology
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Neutrophils / immunology*
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Neutrophils / metabolism*
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Neutrophils / microbiology
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Phosphorylation
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Receptors, Immunologic / biosynthesis*
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Receptors, Immunologic / blood
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Receptors, Immunologic / genetics
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Receptors, Immunologic / physiology*
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Triggering Receptor Expressed on Myeloid Cells-1
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Tyrosine / blood
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Up-Regulation / immunology
Substances
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Adaptor Proteins, Signal Transducing
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Biomarkers
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Chemokines
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Cytokines
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Immunoglobulins
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Membrane Glycoproteins
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Membrane Proteins
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Receptors, Immunologic
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TREM1 protein, human
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TREM2 protein, human
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TYROBP protein, human
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Triggering Receptor Expressed on Myeloid Cells-1
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Tyrosine
Associated data
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GENBANK/AF196329
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GENBANK/AF213457