Towards a circuit engineering discipline

Curr Biol. 2000 Apr 20;10(8):R318-20. doi: 10.1016/s0960-9822(00)00440-1.

Abstract

Genetic circuits can now be engineered that perform moderately complicated switching functions or exhibit predictable dynamical behavior. These 'forward engineering' techniques may have to be combined with directed evolution techniques to produce robustness comparable with naturally occurring circuits.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Escherichia coli / genetics*
  • Gene Expression Regulation, Bacterial*
  • Genes, Bacterial*
  • Green Fluorescent Proteins
  • Isopropyl Thiogalactoside / pharmacology
  • Luminescent Proteins
  • Protein Engineering
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Transcription, Genetic*

Substances

  • Luminescent Proteins
  • Repressor Proteins
  • Green Fluorescent Proteins
  • Isopropyl Thiogalactoside