Mitochondrial control of cell death

G Kroemer; J C Reed

doi:10.1038/74994

Mitochondrial control of cell death

Nat Med. 2000 May;6(5):513-9. doi: 10.1038/74994.

Authors

G Kroemer¹, J C Reed

Affiliation

¹ Centre National de la Recherche Scientifique, CNRS-ULR1599, Institut Gustave Roussy 24 rue Calmette Desmoulins, F-94805 Villejuif. [email protected]

PMID: 10802706
DOI: 10.1038/74994

Abstract

In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Apoptosis / physiology*
Disease
Intracellular Membranes / physiology*
Mitochondria / physiology*
Models, Biological
Permeability