Identification of PML/RARalpha rearrangements in suspected acute promyelocytic leukemia using fluorescence in situ hybridization of bone marrow smears: a comparison with cytogenetics and RT-PCR in MRC ATRA trial patients. MRC Adult Leukaemia Working Party

Leukemia. 2000 May;14(5):950-3. doi: 10.1038/sj.leu.2401688.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow / pathology*
  • Chromosomes, Human, Pair 15
  • Chromosomes, Human, Pair 17
  • Cytogenetics
  • Gene Rearrangement*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Leukemia, Promyelocytic, Acute / genetics*
  • Leukemia, Promyelocytic, Acute / pathology*
  • Neoplasm Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Translocation, Genetic
  • Tretinoin / therapeutic use

Substances

  • Antineoplastic Agents
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
  • Tretinoin