Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis

Ren Fail. 2000 Mar;22(2):245-51. doi: 10.1081/jdi-100100869.

Abstract

We report a case of reversible acute renal failure after cefotaxime treatment in a patient affected by non-Hodgkin lymphoma. Renal biopsy showed necrotizing vasculitis associated with eosinophil-rich interstitial inflammatory infiltrates and patchy infiltrates of CD20+ lymphoid cells. High serum p-ANCA titers were also detected. Drug withdrawal was closely related with recovery of renal function and disappearance of ANCA. Acute renal failure therefore represented a consequence of ANCA-mediated renal vasculitis and acute interstitial nephritis related to cefotaxime treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers / blood
  • Biopsy
  • Cephalosporins / adverse effects*
  • Humans
  • Lymphoma, B-Cell / complications
  • Lymphoma, B-Cell / drug therapy
  • Male
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / immunology
  • Nephritis, Interstitial / pathology
  • Peroxidase / immunology*
  • Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*
  • Vasculitis, Leukocytoclastic, Cutaneous / immunology
  • Vasculitis, Leukocytoclastic, Cutaneous / pathology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Biomarkers
  • Cephalosporins
  • Peroxidase