Abstract
We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation.
MeSH terms
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Adult
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Carbon Radioisotopes
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Caudate Nucleus / diagnostic imaging
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Caudate Nucleus / metabolism*
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Dopamine Antagonists / pharmacokinetics
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Female
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Flumazenil / pharmacokinetics*
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GABA Modulators / pharmacokinetics*
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Humans
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Huntington Disease / diagnostic imaging*
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Huntington Disease / metabolism
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Male
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Middle Aged
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Putamen / diagnostic imaging
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Putamen / metabolism*
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Raclopride / pharmacokinetics
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Receptors, GABA-A / metabolism*
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Tomography, Emission-Computed*
Substances
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Carbon Radioisotopes
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Dopamine Antagonists
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GABA Modulators
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Receptors, GABA-A
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Flumazenil
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Raclopride