CRM646-A and -B, novel fungal metabolites that inhibit heparinase

J Antibiot (Tokyo). 2000 Feb;53(2):211-4. doi: 10.7164/antibiotics.53.211.
No abstract available

Publication types

  • Letter

MeSH terms

  • Acremonium / chemistry*
  • Acremonium / metabolism*
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Fermentation
  • Heparin / metabolism
  • Heparin Lyase / antagonists & inhibitors*
  • Hydroxybenzoates / chemistry*
  • Hydroxybenzoates / isolation & purification
  • Hydroxybenzoates / pharmacology*
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Melanoma / drug therapy
  • Melanoma / pathology
  • Mice
  • Molecular Structure
  • Neoplasm Invasiveness
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • CRM646 A
  • CRM646 B
  • Enzyme Inhibitors
  • Hydroxybenzoates
  • Heparin
  • Heparin Lyase