Abstract
[reaction: see text] We have analyzed the different catalytic effects of surfactant aggregates upon the rate-determining hydroxide ion induced deprotonation reaction of 1. Vesicles are more effective catalysts than micelles, most likely providing a more apolar microenvironment at the substrate binding sites. We suggest that this leads to a catalytic reaction involving less strongly hydrated hydroxide ions. In the case of DODAB and DODAC vesicles, binding of cholesterol to the bilayer further increases the catalytic efficiency.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Carbon / chemistry
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Catalysis / drug effects
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Cholesterol / pharmacology
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Kinetics
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Liposomes / chemistry
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Liposomes / pharmacology*
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Micelles
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Protons*
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Quaternary Ammonium Compounds / chemistry
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Quaternary Ammonium Compounds / pharmacology
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Surface-Active Agents / chemistry
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Surface-Active Agents / pharmacology
Substances
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Anti-Infective Agents
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Liposomes
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Micelles
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Protons
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Quaternary Ammonium Compounds
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Surface-Active Agents
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didodecyldimethylammonium
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dimethyldioctadecylammonium
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Carbon
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Cholesterol