Stimulation of platelets and endothelial cells by mildly oxidized LDL proceeds through activation of lysophosphatidic acid receptors and the Rho/Rho-kinase pathway. Inhibition by lovastatin

Ann N Y Acad Sci. 2000 Apr:905:282-6. doi: 10.1111/j.1749-6632.2000.tb06561.x.

Authors

M Essler¹, M Retzer, M Bauer, K J Zangl, G Tigyi, W Siess

Affiliation

¹ Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Universität München, Germany.

PMID: 10818465
DOI: 10.1111/j.1749-6632.2000.tb06561.x

No abstract available

MeSH terms

Blood Platelets / drug effects
Blood Platelets / metabolism
Endothelium / drug effects*
Endothelium / metabolism
Humans
Intracellular Signaling Peptides and Proteins
Lipoproteins, LDL / pharmacology*
Lovastatin / pharmacology*
Platelet Activation / drug effects
Protein Serine-Threonine Kinases / metabolism*
Receptors, Cell Surface / agonists*
Receptors, G-Protein-Coupled*
Receptors, Lysophosphatidic Acid
Signal Transduction / drug effects
rho-Associated Kinases

Substances

Intracellular Signaling Peptides and Proteins
Lipoproteins, LDL
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Receptors, Lysophosphatidic Acid
oxidized low density lipoprotein
Lovastatin
Protein Serine-Threonine Kinases
rho-Associated Kinases