Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp. TP-A0316. II. Structure determination

Y Igarashi; K Takagi; Y Kan; K Fujii; K Harada; T Furumai; T Oki

doi:10.7164/antibiotics.53.233

Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp. TP-A0316. II. Structure determination

J Antibiot (Tokyo). 2000 Mar;53(3):233-40. doi: 10.7164/antibiotics.53.233.

Authors

Y Igarashi¹, K Takagi, Y Kan, K Fujii, K Harada, T Furumai, T Oki

Affiliation

¹ Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.

PMID: 10819293
DOI: 10.7164/antibiotics.53.233

Abstract

Structures of arisostatins A and B were determined by spectroscopic analyses. Arisostatins were found to be new analogs of tetrocarcin A and possess an iso-butanoyldigitoxose unit instead of the acetyldigitoxose one. NMR analyses of arisostatins and tetrocarcin A led to the revision of the anomeric configurations in the tetrasaccharide moiety of tetrocarcin A.

MeSH terms

Aminoglycosides*
Anti-Bacterial Agents / chemistry*
Antibiotics, Antineoplastic / chemistry*
Carbohydrate Conformation
Carbohydrate Sequence
Macrolides*
Magnetic Resonance Spectroscopy
Mass Spectrometry / methods
Micromonospora / metabolism*
Models, Molecular
Molecular Sequence Data
Molecular Structure
Spectrophotometry / methods

Substances

Aminoglycosides
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Macrolides
arisostatin A
arisostatin B
tetrocarcin A