1,7-Asymmetric induction in a nitrogen ring expansion process facilitated by in situ tethering

Org Lett. 1999 Aug 12;1(3):495-7. doi: 10.1021/ol990685b.

Abstract

[formula: see text] There are only a few methods for the asymmetric ring expansion of prochiral ketones. Symmetrically substituted cyclohexanones can be converted to the corresponding ring-expanded caprolactam with excellent 1,7-diastereoselectivity (> or = 93% ds) and yields (> or = 86%), using a chiral hydroxy azide-mediated Schmidt reaction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Caprolactam / analogs & derivatives*
  • Caprolactam / chemical synthesis*
  • Cyclohexanones / chemistry*
  • Nitrogen*
  • Stereoisomerism

Substances

  • Cyclohexanones
  • Caprolactam
  • Nitrogen