Abstract
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Antibodies, Monoclonal / therapeutic use
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Autoimmune Diseases / immunology*
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CD40 Antigens / immunology
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Callithrix / immunology*
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Cebidae
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Cercopithecidae
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Chimera
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Demyelinating Diseases
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Desensitization, Immunologic
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Disease Models, Animal*
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Disease Susceptibility
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Encephalomyelitis, Autoimmune, Experimental / immunology*
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Encephalomyelitis, Autoimmune, Experimental / pathology
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Encephalomyelitis, Autoimmune, Experimental / therapy
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Genes, MHC Class II
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Histocompatibility Antigens / immunology
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Immunosuppressive Agents / therapeutic use
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Immunotherapy
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Interferon-beta / therapeutic use
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Multiple Sclerosis / immunology*
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Rats
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Rats, Inbred Lew
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Receptors, Antigen, T-Cell / genetics
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Rodentia
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Rolipram / therapeutic use
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Species Specificity
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Twins
Substances
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Antibodies, Monoclonal
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CD40 Antigens
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Histocompatibility Antigens
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Immunosuppressive Agents
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Receptors, Antigen, T-Cell
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Interferon-beta
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Rolipram