Impaired verbal memory is associated with impaired motor performance in schizophrenia: relationship to brain structure

Schizophr Res. 2000 May 25;43(1):21-32. doi: 10.1016/s0920-9964(99)00179-6.

Abstract

Deficient ability to take advantage of predictable elements in the performance of cognitive tasks has been proposed as an underlying factor for a number of deviances in schizophrenia. In a schizophrenic sample (n=39), we propose and test the view that certain memory and motor anomalies arise because of a compromise in the capacity to take advantage of the redundant (predictable) features of cognitive tasks. Results demonstrate a relationship between reduced capacity to take advantage of predictable features of two different cognitive processing tasks, one verbal memory, and the other motor. Poorer verbal recall on high-redundancy word lists was associated with a reduced ability to produce synchronous finger tapping in response to a high redundancy auditory stimulus, and inversely correlated with formal thought disorder ratings. These relationships, we suggest, reflect a specific and common schizophrenic deficit in the use of redundancies, not attributable to a generalized deficiency in performance. Structural imaging evidence from a subsample of these subjects (n=16) implicates frontal areas as the locus of this cognitive impairment.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Attention / physiology
  • Brain Mapping
  • Cerebral Cortex / physiopathology
  • Female
  • Frontal Lobe / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mental Recall / physiology*
  • Middle Aged
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Psychomotor Disorders / diagnosis
  • Psychomotor Disorders / physiopathology*
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Verbal Learning / physiology*