Human leukocyte antigen-G: immunotolerant major histocompatibility complex molecule in transplantation

World J Surg. 2000 Jul;24(7):819-22. doi: 10.1007/s002680010131.

Abstract

HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the fetal-maternal interface, where it plays a role in maternofetal tolerance. In this review, attempts were made to summarize the current state of knowledge of the effects of HLA-G on both natural killer cell and T cell functions and their implications in transplantation.

Publication types

  • Review

MeSH terms

  • Graft Rejection / immunology
  • HLA Antigens / immunology*
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation / immunology
  • Major Histocompatibility Complex / immunology*
  • T-Lymphocytes / immunology*
  • Transplantation Immunology / immunology*
  • Transplantation, Heterologous / immunology
  • Transplantation, Homologous / immunology

Substances

  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I