Secondary acute nonlymphocytic leukemia following successful chemotherapy combining cisplatin, doxorubicin, and cyclophosphamide for stage IV epithelial ovarian cancer

Arch Gynecol Obstet. 2000 Apr;263(4):206-7. doi: 10.1007/s004040050285.

Abstract

Although chemotherapy is indispensable for the treatment of ovarian cancer, secondary acute leukemia has become increasingly important as one of the most unfavorable late effects according to widespread long-term chemotherapy. We report a patient suffering from acute nonlymphocytic leukemia (ANLL) 3 years after treatment for stage IV ovarian cancer began.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Bone Marrow / pathology
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Cystadenocarcinoma, Mucinous / drug therapy*
  • Cystadenocarcinoma, Mucinous / secondary
  • Cystadenocarcinoma, Mucinous / surgery
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Doxorubicin / administration & dosage
  • Doxorubicin / adverse effects
  • Female
  • Humans
  • Idarubicin / therapeutic use
  • Leukemia, Myeloid, Acute / chemically induced*
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / pathology
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary
  • Middle Aged
  • Mitoxantrone / therapeutic use
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Prednisolone / therapeutic use
  • Remission Induction / methods
  • Reoperation

Substances

  • Antibiotics, Antineoplastic
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Alkylating
  • Cytarabine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone
  • Mitoxantrone
  • Cisplatin
  • Idarubicin
  • Daunorubicin