Enteropathogenic Escherichia coli (EPEC) are known to cause infantile enteritis. We studied the prevalence of EPEC in paediatric patients with acute and persistent diarrhoea. A total of 56 stool samples from paediatric patients were studied. There were 28 significant bacterial isolates. Of these 21 were untypable E. coli, 5 were typable E. coli, four of which belonged to members considered to be enteropathogenic. Non E. coli isolates grown in pure culture were one each of Pseudomonas aeruginosa and Citrobacter freundi. The study reveals the definitive role of EPEC in childhood diarrhoea at all age groups and emphasizes the need for characterisation of all significant E. coli isolates in this age group.