Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR Val30Met)

Y Ando; Y Ohtsu; H Terazaki; K Kibayashi; M Nakamura; E Ando; N Matsunaga; K Obayashi; M Uchino; M Ando; S Tsunenari

doi:10.3109/13506120009146251

Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR Val30Met)

Amyloid. 2000 Jun;7(2):133-6. doi: 10.3109/13506120009146251.

Authors

Y Ando¹, Y Ohtsu, H Terazaki, K Kibayashi, M Nakamura, E Ando, N Matsunaga, K Obayashi, M Uchino, M Ando, S Tsunenari

Affiliation

¹ First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.

PMID: 10842717
DOI: 10.3109/13506120009146251

Abstract

Twenty-nine-year-old twin brothers having the amyloidogenic transthyretin (ATTR) Val30Met gene developed the clinical symptoms of familial amyloidotic polyneuropathy (FAP) in 1995. The twins had the same educational background and lived in the same district. FAP manifestations were similar in both cases, although electromyographic examinations revealed sensorimotor polyneuropathy in No. 1 and sensory polyneuropathy in No. 2. DNA analysis revealed that they were monozygotic twins. In addition to environmental factors, genetic factors may play an important role in determining the onset of FAP.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Amyloid Neuropathies* / genetics
Humans
Male
Mutation
Prealbumin / genetics*
Twins, Monozygotic*

Substances

Prealbumin