A new class of highly cytotoxic diketopiperazines

Bioorg Med Chem Lett. 2000 May 15;10(10):1019-20. doi: 10.1016/s0960-894x(00)00152-9.

Abstract

The discovery of a novel class of diketopiperazines possessing potent cytotoxic activity is described.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Combinatorial Chemistry Techniques
  • DNA / metabolism*
  • Drug Evaluation, Preclinical / methods
  • Indoles / chemical synthesis*
  • Indoles / metabolism
  • Indoles / pharmacology*
  • Inhibitory Concentration 50
  • Leukemia L1210 / drug therapy
  • Piperazines / chemical synthesis*
  • Piperazines / metabolism
  • Piperazines / pharmacology*
  • Structure-Activity Relationship

Substances

  • 3,9-bis(dimethylaminopropanoyl)piperazino(1,2-a - 5,4-a')diindole-6,12-dione
  • Indoles
  • Piperazines
  • DNA