The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat

Chest. 2000 May;117(5 Suppl 1):299S-302S.

Authors

U P Kodavanti¹, M C Jackson, A D Ledbetter, B C Starcher, P A Evansky, A Harewood, D W Winsett, D L Costa

Affiliation

¹ Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environment Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

PMID: 10843962

No abstract available

Publication types

Comparative Study

MeSH terms

Air Pollutants / toxicity*
Animals
Bronchoalveolar Lavage Fluid / chemistry
Bronchoalveolar Lavage Fluid / cytology
Cell Count
Disease Models, Animal
Drug Synergism
Instillation, Drug
L-Lactate Dehydrogenase / metabolism
Lung Diseases, Obstructive / chemically induced*
Lung Diseases, Obstructive / pathology
Lung Diseases, Obstructive / physiopathology
Male
Neutrophils / pathology
Pancreatic Elastase / administration & dosage
Pancreatic Elastase / toxicity*
Rats
Rats, Inbred BN
Rats, Sprague-Dawley
Respiratory Function Tests
Sulfur Dioxide / administration & dosage
Sulfur Dioxide / toxicity*
Trachea

Substances

Air Pollutants
Sulfur Dioxide
L-Lactate Dehydrogenase
Pancreatic Elastase