Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression

J Exp Med. 1976 Jul 1;144(1):10-9. doi: 10.1084/jem.144.1.10.

Abstract

The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivity (DTH) and for helper functions were found to be Ly-1+,2- in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly-1-,2+. Unlike some primed helper cells, T cells involved in DTH were Ia-. Suppressor cells in the system were Ia+.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibody Formation
  • Antigen-Antibody Reactions
  • Antigens
  • Cytotoxicity Tests, Immunologic
  • Hypersensitivity, Delayed / immunology*
  • Immunosuppression Therapy*
  • Lymph Nodes / immunology
  • Mice
  • Mice, Inbred Strains
  • Phenotype
  • Spleen / immunology
  • T-Lymphocytes / immunology*

Substances

  • Antigens