Abstract
4-1BB is a member of the tumor necrosis factor receptor superfamily. The receptor functions mainly as a costimulatory molecule in T lymphocytes. In addition, several lines of evidence have shown that interactions between 4-1BB and its ligand are involved in the antigen presentation process and the generation of cytotoxic T cells. Recent studies, however, have demonstrated that 4-1BB plays more diverse roles: Signals through 4-1BB are important for long-term survival of CD8+ T cells and the induction of helper T cell anergy. Clinically, there is great interest in 4-1BB, because T-cell activation induced by anti-4-1BB monoclonal antibodies is highly efficient in the eradication of established tumor cells in mice. Now, since mice deficient in 4-1BB or the 4-1BB ligand are available, subtle roles played by 4-1BB may be revealed in the near future.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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4-1BB Ligand
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Amino Acid Sequence
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Animals
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Antigens, CD
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Humans
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Lymphocyte Activation
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism
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Mice
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Molecular Sequence Data
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Protein Structure, Tertiary
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Receptors, Nerve Growth Factor / chemistry
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Receptors, Nerve Growth Factor / genetics*
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Receptors, Nerve Growth Factor / metabolism*
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Receptors, Tumor Necrosis Factor / chemistry
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Receptors, Tumor Necrosis Factor / genetics*
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Receptors, Tumor Necrosis Factor / metabolism*
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Sequence Alignment
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Signal Transduction
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
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Tumor Necrosis Factor Receptor Superfamily, Member 9
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Tumor Necrosis Factor-alpha / chemistry
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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4-1BB Ligand
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Antigens, CD
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Membrane Glycoproteins
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Receptors, Nerve Growth Factor
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Receptors, Tumor Necrosis Factor
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TNFRSF9 protein, human
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TNFSF9 protein, human
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Tnfrsf9 protein, mouse
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Tnfsf9 protein, mouse
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Tumor Necrosis Factor Receptor Superfamily, Member 9
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Tumor Necrosis Factor-alpha