Seventeen more novel HLA-A locus alleles

Tissue Antigens. 2000 Apr;55(4):369-73. doi: 10.1034/j.1399-0039.2000.550412.x.

Abstract

This paper describes seventeen novel HLA-A locus alleles: A*0106, *0235, *0236, *0237, *1105, *2302, *2303, *24032, *2422, *2424, *2503, *2613, *3007, *3203, *3204, *6809 and *6810. All alleles were identified due to unexpected probe reaction patterns during routine SSOP typing. Exons 2 and 3 of these alleles were subsequently characterized by DNA sequencing. The alleles represent a shuffling of sequence motifs, likely by interallelic conversion, expanding the diversity of the HLA system.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Base Sequence
  • Exons / genetics
  • Genetic Variation*
  • HLA-A Antigens / genetics*
  • HLA-A Antigens / immunology
  • Humans
  • Molecular Sequence Data
  • Sequence Analysis, DNA

Substances

  • HLA-A Antigens