Abstract
A series of new 1,2-dihydro and 1,2,3,4-tetrahydroquinolines, synthesized from the corresponding propargylaniline intermediates, have been developed as antioxidants for the potential treatment of pathologies implicating central oxidative stress.
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Cell Line
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Electrons
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Ethoxyquin / chemistry
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Hippocampus / cytology
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Hippocampus / drug effects
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Hippocampus / metabolism
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Isoquinolines / chemistry
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Isoquinolines / pharmacology
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Mice
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Neurons / drug effects
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / pharmacology
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Oxidants / toxicity
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Oxidative Stress / drug effects
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Quinolinic Acids / chemical synthesis*
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Quinolinic Acids / pharmacology*
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Structure-Activity Relationship
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Vitamin E / pharmacology
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tert-Butylhydroperoxide / antagonists & inhibitors
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tert-Butylhydroperoxide / toxicity
Substances
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Antioxidants
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Isoquinolines
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Neuroprotective Agents
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Oxidants
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Quinolinic Acids
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Vitamin E
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tert-Butylhydroperoxide
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Ethoxyquin