The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes

Palliat Med. 2000 May;14(3):205-7. doi: 10.1191/026921600666997498.

Abstract

Varying concentrations of octreotide acetate (Sandostatin) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37 degrees C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37 degrees C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Opioid / chemistry*
  • Drug Combinations
  • Drug Stability
  • Drug Storage
  • Gastrointestinal Agents / chemistry*
  • Heroin / chemistry*
  • Humans
  • Octreotide / chemistry*
  • Palliative Care
  • Syringes

Substances

  • Analgesics, Opioid
  • Drug Combinations
  • Gastrointestinal Agents
  • Heroin
  • Octreotide