Emergence of fluconazole-resistant sterol 14-demethylase P450 (CYP51) in Candida albicans is a model demonstrating the diversification mechanism of P450

Arch Biochem Biophys. 2000 Jul 1;379(1):170-1. doi: 10.1006/abbi.2000.1852.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antifungal Agents / pharmacology
  • Candida albicans / enzymology*
  • Candida albicans / genetics
  • Cell Membrane / enzymology
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Resistance / genetics*
  • Enzyme Inhibitors / pharmacology
  • Escherichia coli
  • Fluconazole / pharmacology*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Genes, Fungal / genetics
  • Oxidoreductases / genetics*
  • Oxidoreductases / metabolism
  • Polymorphism, Genetic
  • Sterol 14-Demethylase
  • Transformation, Genetic

Substances

  • Antifungal Agents
  • Enzyme Inhibitors
  • Fungal Proteins
  • Fluconazole
  • Cytochrome P-450 Enzyme System
  • Oxidoreductases
  • Sterol 14-Demethylase