Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice

Brain Res. 2000 Jun 30;869(1-2):241-3. doi: 10.1016/s0006-8993(00)02392-1.

Abstract

Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-10 in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 microg/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System / cytology
  • Central Nervous System / metabolism*
  • Interleukin-10 / deficiency*
  • Interleukin-6 / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Interleukin-10