Abstract
The relationship of Epstein-Barr virus (EBV), type I human T-cell lymphotropic virus (HTLV-I), and parvovirus B19 to histiocytic necrotizing lymphadenitis was studied prospectively in 10 Taiwanese patients using materials obtained by fine-needle aspiration and lymph node biopsy. The presence of EBV was detected by in situ hybridization for EBV-encoded RNA expression. Immunocytochemistry was used to detect virus-encoded protein for EBV and parvovirus B19. DNA in situ hybridization and polymerase chain reaction were performed to determine the existence of HTLV-I provirus. Expressions of EBV-encoded RNA and Fas ligand were detected in all cases. Expression of EBV-encoded protein was identified in only 1 case. Neither HTLV-I nor parvovirus B19 was detected in any case.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Biopsy, Needle
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DNA Primers / chemistry
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DNA Probes / chemistry
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DNA Virus Infections / pathology
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DNA Virus Infections / virology*
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DNA, Viral / analysis
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Female
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HTLV-I Infections / pathology
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HTLV-I Infections / virology*
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification*
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Histiocytic Necrotizing Lymphadenitis / pathology
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Histiocytic Necrotizing Lymphadenitis / virology*
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / isolation & purification*
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Humans
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Immunohistochemistry
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In Situ Hybridization
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Lymph Nodes / pathology
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Lymph Nodes / virology
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Male
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Parvovirus B19, Human / genetics
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Parvovirus B19, Human / isolation & purification*
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Polymerase Chain Reaction
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Prospective Studies
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RNA, Viral / analysis
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Taiwan
Substances
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DNA Primers
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DNA Probes
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DNA, Viral
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Epstein-Barr virus encoded RNA 1
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RNA, Viral