Abstract
Definition of cellular responses to cytokines often involves cross-communication through their respective receptors. Here, signaling by interferon-gamma (IFN-gamma) is shown to depend on the IFN-alpha/beta receptor components. Although these IFNs transmit signals through distinct receptor complexes, the IFN-alpha/beta receptor component, IFNAR1, facilitates efficient assembly of IFN-gamma-activated transcription factors. This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. This aspect of signaling cross talk by IFNs may apply to other cytokines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Membrane / metabolism*
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Cells, Cultured
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Cytopathogenic Effect, Viral
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DNA-Binding Proteins / metabolism
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Dimerization
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Encephalomyocarditis virus / drug effects
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Encephalomyocarditis virus / physiology
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Interferon Type I / metabolism*
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Interferon gamma Receptor
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Interferon-alpha / genetics
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Interferon-alpha / metabolism
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Interferon-alpha / pharmacology
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Interferon-beta / genetics
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Interferon-beta / metabolism
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Interferon-beta / pharmacology
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Interferon-gamma / metabolism*
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Interferon-gamma / pharmacology
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Janus Kinase 1
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Janus Kinase 2
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Membrane Proteins
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Mice
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Phosphorylation
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Phosphotyrosine / metabolism
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins*
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Receptor Cross-Talk*
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Receptor, Interferon alpha-beta
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Receptors, Interferon / genetics
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Receptors, Interferon / metabolism*
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Recombinant Proteins
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STAT1 Transcription Factor
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Signal Transduction*
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Trans-Activators / metabolism
Substances
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DNA-Binding Proteins
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Ifnar1 protein, mouse
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Interferon Type I
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Interferon-alpha
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Membrane Proteins
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Proto-Oncogene Proteins
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Receptors, Interferon
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Recombinant Proteins
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STAT1 Transcription Factor
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Stat1 protein, mouse
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Trans-Activators
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Receptor, Interferon alpha-beta
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Phosphotyrosine
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Interferon-beta
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Interferon-gamma
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Protein-Tyrosine Kinases
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Jak1 protein, mouse
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Jak2 protein, mouse
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Janus Kinase 1
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Janus Kinase 2