Abstract
The comparative evaluation of the diagnostic value of the polymerase chain reaction (PCR) and the enzyme immunoassay (EIA) in the detection of intrauterine infection (IUI) in 48 newborn infants with cerebral lesions was made. Tests for the presence of the infective agents of IUI, most frequently occurring in the region (Cytomegalovirus, Herpes simplex virus, Chlamydia trachomatis), were carried out. The levels of serum IgA, IgG and IgM were evaluated in the course of the primary screening of IUI. Laboratory samples for PCR from infants with IUI were selected at random. The study demonstrated that in PCR the frequency of positive results was significantly greater than in EIA.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Brain Diseases / cerebrospinal fluid
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Brain Diseases / diagnosis*
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Chi-Square Distribution
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Chlamydia Infections / cerebrospinal fluid
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Chlamydia Infections / diagnosis*
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Chlamydia trachomatis*
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Cytomegalovirus Infections / cerebrospinal fluid
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Cytomegalovirus Infections / diagnosis*
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Evaluation Studies as Topic
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Fetal Diseases / cerebrospinal fluid
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Fetal Diseases / diagnosis*
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Herpes Simplex / cerebrospinal fluid
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Herpes Simplex / diagnosis*
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Humans
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Immunoenzyme Techniques* / statistics & numerical data
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Immunoglobulins / cerebrospinal fluid
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Infant, Newborn
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Polymerase Chain Reaction / methods*
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Polymerase Chain Reaction / statistics & numerical data
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Statistics, Nonparametric