Abstract
Osteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 expression (n=24) showed a significantly increased vascularity (P<0.0014, Mann-Whitney U test). Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2 (P=0.016, Wilcoxon's test). These results suggest that NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Neoplasms / blood supply
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Bone Neoplasms / metabolism*
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Bone Neoplasms / mortality
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Humans
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Neoplasm Proteins / metabolism*
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Neovascularization, Pathologic / metabolism*
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Nerve Tissue Proteins / metabolism*
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Neuropilin-1
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Osteosarcoma / blood supply
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Osteosarcoma / metabolism*
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Osteosarcoma / mortality
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Prognosis
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RNA, Messenger / metabolism
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Receptor Protein-Tyrosine Kinases / metabolism
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Receptors, Growth Factor / metabolism
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Receptors, Vascular Endothelial Growth Factor
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Survival Rate
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Transplantation, Heterologous
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Tumor Cells, Cultured
Substances
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Neoplasm Proteins
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Nerve Tissue Proteins
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RNA, Messenger
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Receptors, Growth Factor
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Neuropilin-1
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Receptor Protein-Tyrosine Kinases
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Receptors, Vascular Endothelial Growth Factor