[Cellular neurothekeoma, a rare cutaneous tumor. Anatomo-clinical and immunohistochemical study of 2 cases]

Ann Pathol. 2000 May;20(3):225-7.
[Article in French]

Abstract

Cellular neurothekeoma is an unusual cutaneous tumor described in 1986. We report two new cases in 14-year-old girls. Both tumors measured less than one centimeter and were located on the forearm and the shoulder. They had a plexiform architecture and were developed in the dermis and the dermo-hypodermic junction. Spindle and epithelioid tumor cells were immunoreactive for vimentin, NKI-C3, NSE, CD68 and smooth muscle actin. There was no recurrence 2 and 7 months after the operation. Cellular neurothekeoma is a benign tumor. Its histogenesis is still unknown. Histological and immunohistochemical features, with positivity of the tumor cells for NKI-C3, a non specific melanocytic marker, and negativity for S-100 protein and HMB-45, allow to differentiate cellular neurothekeoma from myxoid neurothekeoma and melanocytic tumors.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Actins / analysis
  • Adolescent
  • Antigens, CD / analysis
  • Antigens, Differentiation, Myelomonocytic / analysis
  • Biomarkers, Tumor / analysis
  • Female
  • Humans
  • Neurothekeoma / chemistry*
  • Neurothekeoma / pathology*
  • Neurothekeoma / surgery
  • Phosphopyruvate Hydratase / analysis
  • Skin Neoplasms / chemistry*
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Vimentin / analysis

Substances

  • Actins
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers, Tumor
  • CD68 antigen, human
  • Vimentin
  • Phosphopyruvate Hydratase