New dopaminergic neurons in Parkinson's disease striatum

Lancet. 2000 Jul 1;356(9223):44-5. doi: 10.1016/S0140-6736(00)02437-5.

Abstract

A new population of dopaminergic neurons has been identified in Parkinson's disease striatum. These neurons are sufficiently numerous to have an important effect on dopaminergic function in the striatum.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carrier Proteins / metabolism
  • Cell Count
  • Cell Differentiation
  • Corpus Striatum / enzymology
  • Corpus Striatum / pathology*
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Humans
  • Interneurons / metabolism
  • Interneurons / pathology
  • Levodopa / metabolism
  • Levodopa / pharmacology
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Nerve Tissue Proteins*
  • Neurons / drug effects
  • Neurons / enzymology
  • Neurons / pathology*
  • Parkinson Disease / enzymology
  • Parkinson Disease / pathology*
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Levodopa
  • Tyrosine 3-Monooxygenase
  • Dopamine