Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains

Antimicrob Agents Chemother. 2000 Aug;44(8):2211-3. doi: 10.1128/AAC.44.8.2211-2213.2000.

Abstract

In vitro activities of seven fluoroquinolones against 140 clinical Acinetobacter baumannii isolates representing 138 different strain types were determined. The rank order of activity was clinafloxacin > gatifloxacin > levofloxacin > trovafloxacin > gemifloxacin = moxifloxacin > ciprofloxacin. The 31 outbreak-related A. baumannii strains were significantly more resistant than were 109 sporadic strains.

Publication types

  • Comparative Study

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter Infections / epidemiology
  • Acinetobacter Infections / microbiology
  • Anti-Infective Agents / pharmacology*
  • Aza Compounds*
  • Ciprofloxacin / pharmacology
  • Disease Outbreaks
  • Drug Resistance, Microbial / physiology
  • Fluoroquinolones*
  • Gatifloxacin
  • Gemifloxacin
  • Germany / epidemiology
  • Humans
  • Levofloxacin
  • Microbial Sensitivity Tests
  • Moxifloxacin
  • Naphthyridines / pharmacology
  • Ofloxacin / pharmacology
  • Quinolines*

Substances

  • Anti-Infective Agents
  • Aza Compounds
  • Fluoroquinolones
  • Naphthyridines
  • Quinolines
  • Ciprofloxacin
  • Levofloxacin
  • clinafloxacin
  • trovafloxacin
  • Ofloxacin
  • Gatifloxacin
  • Gemifloxacin
  • Moxifloxacin