Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1

D Hourcade; M K Liszewski; M Krych-Goldberg; J P Atkinson

doi:10.1016/s0162-3109(00)80296-9

Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1

Immunopharmacology. 2000 Aug;49(1-2):103-16. doi: 10.1016/s0162-3109(00)80296-9.

Authors

D Hourcade¹, M K Liszewski, M Krych-Goldberg, J P Atkinson

Affiliation

¹ Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

PMID: 10904110
DOI: 10.1016/s0162-3109(00)80296-9

Abstract

The Regulators of Complement Activation (RCA) are a fascinating group of proteins that play important roles in innate and acquired immunity. In this review, we examine structure-function aspects of three membrane-bound RCA proteins and discuss the unique impact of their genetic organization on their evolution.

Publication types

Review

MeSH terms

Animals
Antigens, CD / chemistry*
Antigens, CD / genetics
Antigens, CD / physiology
Biological Evolution
CD55 Antigens / chemistry*
CD55 Antigens / genetics
CD55 Antigens / physiology
Complement Activation
Genetic Variation
Humans
Infections / immunology
Membrane Cofactor Protein
Membrane Glycoproteins / chemistry*
Membrane Glycoproteins / genetics
Membrane Glycoproteins / physiology
Protein Structure, Tertiary
Receptors, Complement 3b / chemistry*
Receptors, Complement 3b / genetics
Receptors, Complement 3b / physiology

Substances

Antigens, CD
CD46 protein, human
CD55 Antigens
Membrane Cofactor Protein
Membrane Glycoproteins
Receptors, Complement 3b