An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly

J G Ocejo-Vinyals; M J Lozano; P Sánchez-Velasco; J Escribano de Diego; J E Paz-Miguel; F Leyva-Cobián

doi:10.1136/adc.83.2.165

An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly

Arch Dis Child. 2000 Aug;83(2):165-9. doi: 10.1136/adc.83.2.165.

Authors

J G Ocejo-Vinyals¹, M J Lozano, P Sánchez-Velasco, J Escribano de Diego, J E Paz-Miguel, F Leyva-Cobián

Affiliation

¹ Servicio de Inmunología, Hospital Universitario "Marqués de Valdecilla", Instituto Nacional de la Salud, 39008 Santander, Spain.

Abstract

We describe a girl with DiGeorge anomaly and normal cytogenetic and molecular studies, whose clinical course was complicated by graft versus host disease caused by intrauterine materno-fetal transfusion, and several immunohematological alterations including a monoclonal gammapathy of undetermined significance (first IgG, which subsequently changed to IgM). The main clinical features and pathological findings are discussed.

Publication types

Case Reports

MeSH terms

Child, Preschool
Chimera
Chromosomes, Human, Pair 22 / genetics
DiGeorge Syndrome / complications*
DiGeorge Syndrome / genetics
DiGeorge Syndrome / immunology
Fatal Outcome
Female
Fetomaternal Transfusion / complications*
Fetomaternal Transfusion / genetics
Graft vs Host Disease / complications*
Graft vs Host Disease / immunology
Humans
Immunoglobulin G / immunology
Immunoglobulin M / immunology
Pedigree
Pregnancy
T-Lymphocytes / immunology*

Substances

Immunoglobulin G
Immunoglobulin M