Mitochondrial DNA variants in schizophrenia: association studies

Psychiatr Genet. 2000 Mar;10(1):27-31. doi: 10.1097/00041444-200010010-00005.

Abstract

The frequency of three selected mitochondrial DNA variations was compared between cases with schizophrenia and two groups of unrelated controls: screened adults and neonates. The comparisons were conducted separately among Caucasians and African-Americans. No significant differences were detected, suggesting that the variants may not be associated with schizophrenia. Limitations of the study are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Black People / genetics
  • Black or African American
  • Cytochrome b Group / genetics
  • DNA Mutational Analysis
  • DNA, Mitochondrial / genetics*
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • Humans
  • Infant, Newborn
  • Pennsylvania / epidemiology
  • RNA, Ribosomal / genetics
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • White People / genetics

Substances

  • Cytochrome b Group
  • DNA, Mitochondrial
  • RNA, Ribosomal
  • RNA, ribosomal, 12S