Abstract
Flavanoids bearing a 1,4-benzodioxane moiety [rac-15a, -16a, -17, -18, (-)-15a, (-)-16a] were prepared from protocatechualdehyde (5) and tested for inhibitory activity on the superoxide anion (O2.-) release by human polymorphonuclear leukocytes (PMNLs).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology
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Flavonoids / chemical synthesis*
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Flavonoids / pharmacology
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Humans
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Neutrophils / metabolism
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Structure-Activity Relationship
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Superoxides / metabolism
Substances
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Antioxidants
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Flavonoids
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Superoxides