Abstract
In the past decade, the drive to develop completely human antibodies for human therapy has led to the development of phage display technology. This technology is able to deliver the ultimate in antibody engineering, that is, high-affinity fully human antibodies to any antigen of choice. Here, this application of phage display technology is reviewed, and the many other antibody-engineering avenues this technology offers are highlighted.
MeSH terms
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Animals
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Antibodies, Monoclonal / biosynthesis*
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Antibodies, Monoclonal / chemistry*
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Bacteria / genetics
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Bacteria / metabolism
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Binding Sites, Antibody*
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Biotechnology / methods*
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Humans
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Immunoglobulin Variable Region
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Peptide Library*
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Protein Engineering
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / chemistry
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Ribosomes / genetics
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Ribosomes / metabolism
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Yeasts / genetics
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Yeasts / metabolism
Substances
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Antibodies, Monoclonal
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Immunoglobulin Variable Region
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Peptide Library
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Recombinant Proteins