Penetration by a giant gastric ulcer induced by a nonsteroidal anti-inflammatory drug

I Shimizu; T Horie; H Inoue; T Oshima; M Fujimoto; Y Ozaki; K Yamamoto; A Iuchi; S Ito

doi:10.1055/s-2000-3812

Penetration by a giant gastric ulcer induced by a nonsteroidal anti-inflammatory drug

Endoscopy. 2000 Jul;32(7):539-41. doi: 10.1055/s-2000-3812.

Authors

I Shimizu¹, T Horie, H Inoue, T Oshima, M Fujimoto, Y Ozaki, K Yamamoto, A Iuchi, S Ito

Affiliation

¹ Second Dept. of Internal Medicine, School of Medicine, University of Tokushima, Japan. [email protected]

PMID: 10917187
DOI: 10.1055/s-2000-3812

Abstract

A patient presented with penetration by a giant gastric ulcer resulting from treatment with a nonsteroidal anti-inflammatory drug. A test for Helicobacter pylori proved negative. Treatment with a combination of an inhibitor of gastric acid secretion and prostaglandin substitution therapy with misoprostol resulted in closure of the perforation and cicatrization of the gastric ulcer without the need for laparotomy.

Publication types

Case Reports

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Diclofenac / administration & dosage
Diclofenac / adverse effects*
Follow-Up Studies
Gastroscopy
Humans
Long-Term Care
Low Back Pain / drug therapy*
Male
Middle Aged
Peptic Ulcer Perforation / chemically induced*
Stomach Ulcer / chemically induced*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Diclofenac