Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor

T Mori; N Sato; R Watanabe; S Okamoto; Y Ikeda

doi:10.1038/sj.bmt.1702501

Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor

Bone Marrow Transplant. 2000 Jul;26(2):239-40. doi: 10.1038/sj.bmt.1702501.

Authors

T Mori¹, N Sato, R Watanabe, S Okamoto, Y Ikeda

Affiliation

¹ Keio Bone Marrow Transplant Program, Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

PMID: 10918440
DOI: 10.1038/sj.bmt.1702501

Abstract

We describe a healthy peripheral blood stem cell (PBSC) donor who developed a cutaneous reaction, erythema exsudativum multiforme, during the administration of granulocyte colony-stimulating factor (G-CSF) for mobilization. The cutaneous lesions were located on his hips, apart from the site of G-CSF injection. Treatment with topical corticosteroid was commenced, and the lesions resolved completely within a week. Adverse cutaneous reactions induced by G-CSF have been reported infrequently in healthy donors. Further documentation of cases and their full evaluation will be of great importance for both physicians and PBSC donor.

Publication types

Case Reports

MeSH terms

Adrenal Cortex Hormones / administration & dosage
Adult
Blood Donors*
Erythema Multiforme / chemically induced*
Erythema Multiforme / drug therapy
Granulocyte Colony-Stimulating Factor / administration & dosage
Granulocyte Colony-Stimulating Factor / adverse effects*
Hematopoietic Stem Cell Mobilization / adverse effects
Hematopoietic Stem Cell Transplantation / adverse effects*
Hip / pathology
Humans
Japan
Male
Skin Diseases, Vesiculobullous / chemically induced
Skin Diseases, Vesiculobullous / drug therapy
Transplantation, Homologous / adverse effects

Substances

Adrenal Cortex Hormones
Granulocyte Colony-Stimulating Factor