[Detection of type 6 human herpesvirus (HHV-6) specific DNA sequence in lymphoma tissues by PCR]

Zhonghua Zhong Liu Za Zhi. 1998 May;20(3):196-8.
[Article in Chinese]

Abstract

Objective: To study the relationship between human herpesvirus-6 (HHV-6) and lymphoma in China.

Methods: The specimens of paraffin-embedded lymphoma tissue, leukemia cell lines and normal blood donor peripheral blood lymphocytes(PBL) were examined for the presence of HHV-6 DNA sequence by polymerase chain reaction (PCR).

Results: Of the 52 cases lymphoma studied, HHV-6 DNA sequence was detected in 21 cases; of 43 normal PBL, HHV-6 DNA sequence was detected in 8 cases. The difference was statistically significant (P < 0.05). HHV-6 DNA sequence was also present in two leukemia cell lines.

Conclusion: The results suggest that HHV-6 may be related to lymphoma in China.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Viral / analysis*
  • Herpesvirus 6, Human / genetics*
  • Hodgkin Disease / virology*
  • Humans
  • Lymphoma, Non-Hodgkin / virology*
  • Polymerase Chain Reaction
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
  • Tumor Cells, Cultured

Substances

  • DNA, Viral