Abstract
Four new compounds, three phenanthrene derivatives, aristolochic acid-III methyl ester (1), cepharanone C (2), and sodium 7-hydroxyl-8-methoxyaristolate (3), and the benzoate derivative, sodium 3,4-dimethoxybenzoate (4), together with 53 known compounds were isolated and characterized from the fresh root and stem of Aristolochia cucurbitifolia. Their structures were elucidated by spectral analyses and chemical transformations. The cytotoxicity and antiplatelet activity of the isolated compounds are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoates / chemistry
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Benzoates / isolation & purification
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Benzoates / pharmacology
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Blood Platelets / drug effects
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HL-60 Cells
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HT29 Cells
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Humans
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KB Cells
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Magnoliopsida / chemistry*
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology
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Plant Roots / chemistry
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Plant Stems / chemistry
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
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Tumor Cells, Cultured
Substances
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Benzoates
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Phenanthrenes
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Platelet Aggregation Inhibitors